منابع مشابه
Molecular Magnetic Resonance Imaging of Tumor Response to Therapy
Personalized cancer medicine requires measurement of therapeutic efficacy as early as possible, which is optimally achieved by three-dimensional imaging given the heterogeneity of cancer. Magnetic resonance imaging (MRI) can obtain images of both anatomy and cellular responses, if acquired with a molecular imaging contrast agent. The poor sensitivity of MRI has limited the development of activa...
متن کاملAssessing tumor response to therapy.
Most anticancer drugs are effective only in subgroups of patients, and our current understanding of tumor biology does not allow us to predict accurately which patient will benefit from a specific therapeutic regimen. Various techniques have, therefore, been developed for monitoring tumor response to therapy, but measuring tumor shrinkage on CT represents the current standard. Although response...
متن کاملMultimodality Imaging of Tumor Response to Doxil
PURPOSE Early assessment of tumor responses to chemotherapy could enhance treatment outcomes by ensuring that, from the beginning, treatments meet the individualized needs of patients. In this study, we applied multiple modality molecular imaging techniques to pre-clinical monitoring of early tumor responses to Doxil, focusing on imaging of apoptosis. METHODS Mice bearing UM-SCC-22B human hea...
متن کاملQuantitative Multi-Parametric Magnetic Resonance Imaging of Tumor Response to Photodynamic Therapy
OBJECTIVE The aim of this study was to characterize response to photodynamic therapy (PDT) in a mouse cancer model using a multi-parametric quantitative MRI protocol and to identify MR parameters as potential biomarkers for early assessment of treatment outcome. METHODS CT26.WT colon carcinoma tumors were grown subcutaneously in the hind limb of BALB/c mice. Therapy consisted of intravenous i...
متن کاملImaging surrogates of tumor response to therapy: anatomic and functional biomarkers.
This article addresses the current status of quantitative imaging as a surrogate biomarker for the assessment of tumor response to therapy with non-small cell lung cancer as an example. In addition, the article discusses the limitations of conventional response criteria in the new era of molecular-targeted agents for cancer treatment; the increasing need for more accurate and early response-ass...
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ژورنال
عنوان ژورنال: Journal of Nuclear Medicine
سال: 2013
ISSN: 0161-5505,2159-662X
DOI: 10.2967/jnumed.113.123117